Our Research Story
Modern biological imaging often forces a trade-off between resolution, scale, adaptability, and accessibility. Our research program works across that boundary: we build open and adaptive light-sheet microscopes, scale them from subcellular dynamics to intact tissues, and use them with collaborators to discover how cells and organs are organized and function.
This page presents a curated view rather than a comprehensive bibliography. For the complete record, use the sources below.
Build Open and Adaptive Imaging Systems
Advanced microscopy is most useful when strong optical performance is paired with accessibility, open control, adaptable sample geometry, and reproducible operation.
Combined high-numerical-aperture optics with a versatile sample geometry to support high-resolution imaging across cells, embryos, and tissue sections.
Navigate: an open-source platform for smart light-sheet microscopy
Created an open control platform that turns light-sheet microscopes into programmable systems for intelligent and adaptive acquisition.
Mechanically sheared axially swept light-sheet microscopy
Placed acquired data directly into its spatial context while enlarging the field of view and reducing interpolation-heavy post-processing.
A high-resolution, easy-to-build light-sheet microscope for subcellular imaging
Paired simplified alignment and open-source control with subcellular resolution, lowering the practical barrier to high-performance light-sheet imaging.
Scale from Cells to Whole Tissues
Biological mechanisms span spatial scales, but conventional imaging often forces a choice between detailed local measurements and the tissue context in which those measurements matter.
Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution
Brought isotropic subcellular resolution to millimeter-scale cleared tissues across diverse immersion media.
Isotropic imaging across spatial scales with axially swept light-sheet microscopy
Made ASLM reproducible across expanded samples, living cells, and cleared organisms through detailed build guidance, operating procedures, and software.
Feature-driven whole-tissue imaging with subcellular resolution
Combined centimeter-scale survey imaging with targeted high-resolution interrogation, concentrating acquisition on rare or informative biology.
Discover Biological Mechanisms
The instrumentation is not an endpoint. Its value is demonstrated through biological collaborations that connect molecular organization and cell morphology to cell behavior and whole-organ function.
Showed that talin and vinculin must assemble before mechanical loading for efficient maturation of nascent adhesions.
Blebs promote cell survival by assembling oncogenic signalling hubs
Used three-dimensional imaging to reveal blebs as signaling hubs that support anoikis resistance in melanoma cells.
An epithelial morphogenetic program for maximal urine concentration
Integrated transcriptomics and high-resolution imaging to connect ascending thin-limb epithelial architecture with whole-organ urine-concentrating function.
Explore the complete publication record
This page presents a curated research narrative rather than a comprehensive bibliography. Browse NCBI My Bibliography, Google Scholar, ORCID, or the full CV for the complete record.