Future Releases

The development of COMPASS is an ongoing effort, with future iterations aimed at increasing both complexity and capability to support volumetric imaging across a diverse range of specimens and experimental contexts. Each implementation will be versioned and accompanied by comprehensive documentation, ensuring that researchers can replicate and modify the system at a fraction of the cost of commercial alternatives. To foster open development and community-driven innovation, we encourage users to request features and provide feedback publicly via COMPASS GitHub Issues.

The projected design roadmap includes:

• Sample-scanning light-sheet microscope for imaging cells on glass coverslips.

• Sample-scanning Axially Swept Light-Sheet Microscope (ASLM).

• Laser-scanning Axially Swept Light-Sheet Microscope.

• Sample-scanning Oblique Plane Microscope (OPM).

• Laser-scanning Oblique Plane Microscope.

Beyond these core designs, we aim to develop modular additions that extend COMPASS’s functionality, including optogenetic stimulation for targeted cellular activation and multiplexed imaging for simultaneous readouts of multiple probes. Through this iterative approach, COMPASS will continue evolving as a highly adaptable, cost-effective, and open-source platform for cutting-edge volumetric imaging.